Professional exposure to pesticides and Parkinson disease
Identifieur interne : 000074 ( France/Analysis ); précédent : 000073; suivant : 000075Professional exposure to pesticides and Parkinson disease
Auteurs : Alexis Elbaz [France] ; Jacqueline Clavel [France] ; Paul J. Rathouz [États-Unis] ; Frédéric Moisan [France] ; Jean-Philippe Galanaud [France] ; Bernard Delemotte [France] ; Annick Alpérovitch [France] ; Christophe Tzourio [France]Source :
- Annals of Neurology [ 0364-5134 ] ; 2009-10.
Abstract
Objective: We studied the relation between Parkinson disease (PD) and professional exposure to pesticides in a community‐based case‐control study conducted in a population characterized by a high prevalence of exposure. Our objective was to investigate the role of specific pesticide families and to perform dose‐effect analyses. Methods: PD cases (n = 224) from the Mutualité Sociale Agricole (France) were matched to 557 controls free of PD affiliated with the same health insurance. Pesticide exposure was assessed using a 2‐phase procedure, including a case‐by‐case expert evaluation. Analyses of the relation between PD and professional exposure to pesticides were first performed overall and by broad category (insecticides, fungicides, herbicides). Analyses of 29 pesticide families defined based on a chemical classification were restricted to men. Multiple imputation was used to impute missing values of pesticide families. Data were analyzed using conditional logistic regression, both using a complete‐case and an imputed dataset. Results: We found a positive association between PD and overall professional pesticide use (odds ratio [OR] = 1.8, 95% confidence interval [CI] = 1.1–3.1), with a dose‐effect relation for the number of years of use (p = 0.01). In men, insecticides were associated with PD (OR = 2.2, 95% CI = 1.1–4.3), in particular organochlorine insecticides (OR = 2.4, 95% CI = 1.2–5.0). These associations were stronger in men with older onset PD than in those with younger onset PD, and were characterized by a dose‐effect relation in the former group. Interpretation: Our results support an association between PD and professional pesticide exposure, and show that some pesticides (ie, organochlorine insecticides) may be more particularly involved. Ann Neurol 2009;66:494–504
Url:
DOI: 10.1002/ana.21717
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Main, to step Corpus: 000353
- to stream Main, to step Curation: 000303
- to stream Main, to step Exploration: 000984
- to stream France, to step Extraction: 000074
Links to Exploration step
ISTEX:80A003FEED147605130B49003FBB3D593BF89233Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Professional exposure to pesticides and Parkinson disease</title><author><name sortKey="Elbaz, Alexis" sort="Elbaz, Alexis" uniqKey="Elbaz A" first="Alexis" last="Elbaz">Alexis Elbaz</name></author><author><name sortKey="Clavel, Jacqueline" sort="Clavel, Jacqueline" uniqKey="Clavel J" first="Jacqueline" last="Clavel">Jacqueline Clavel</name></author><author><name sortKey="Rathouz, Paul J" sort="Rathouz, Paul J" uniqKey="Rathouz P" first="Paul J." last="Rathouz">Paul J. Rathouz</name></author><author><name sortKey="Moisan, Frederic" sort="Moisan, Frederic" uniqKey="Moisan F" first="Frédéric" last="Moisan">Frédéric Moisan</name></author><author><name sortKey="Galanaud, Jean Hilippe" sort="Galanaud, Jean Hilippe" uniqKey="Galanaud J" first="Jean-Philippe" last="Galanaud">Jean-Philippe Galanaud</name></author><author><name sortKey="Delemotte, Bernard" sort="Delemotte, Bernard" uniqKey="Delemotte B" first="Bernard" last="Delemotte">Bernard Delemotte</name></author><author><name sortKey="Alperovitch, Annick" sort="Alperovitch, Annick" uniqKey="Alperovitch A" first="Annick" last="Alpérovitch">Annick Alpérovitch</name></author><author><name sortKey="Tzourio, Christophe" sort="Tzourio, Christophe" uniqKey="Tzourio C" first="Christophe" last="Tzourio">Christophe Tzourio</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:80A003FEED147605130B49003FBB3D593BF89233</idno><date when="2009" year="2009">2009</date><idno type="doi">10.1002/ana.21717</idno><idno type="url">https://api.istex.fr/document/80A003FEED147605130B49003FBB3D593BF89233/fulltext/pdf</idno><idno type="wicri:Area/Main/Corpus">000353</idno><idno type="wicri:Area/Main/Curation">000303</idno><idno type="wicri:Area/Main/Exploration">000984</idno><idno type="wicri:Area/France/Extraction">000074</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Professional exposure to pesticides and Parkinson disease</title><author><name sortKey="Elbaz, Alexis" sort="Elbaz, Alexis" uniqKey="Elbaz A" first="Alexis" last="Elbaz">Alexis Elbaz</name><affiliation wicri:level="1"><country xml:lang="fr">France</country><wicri:regionArea>INSERM, U708, Paris</wicri:regionArea><placeName><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="1"><country xml:lang="fr">France</country><wicri:regionArea>UPMC, Univ Paris 06, Paris</wicri:regionArea><placeName><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="1"><country xml:lang="fr">France</country><wicri:regionArea>Département santé‐travail, Institut de Veille Sanitaire, Saint‐Maurice</wicri:regionArea><wicri:noRegion>Saint‐Maurice</wicri:noRegion><wicri:noRegion>Saint‐Maurice</wicri:noRegion></affiliation></author><author><name sortKey="Clavel, Jacqueline" sort="Clavel, Jacqueline" uniqKey="Clavel J" first="Jacqueline" last="Clavel">Jacqueline Clavel</name><affiliation wicri:level="1"><country xml:lang="fr">France</country><wicri:regionArea>INSERM, U754, Villejuif</wicri:regionArea><wicri:noRegion>Villejuif</wicri:noRegion><wicri:noRegion>Villejuif</wicri:noRegion></affiliation><affiliation wicri:level="1"><country xml:lang="fr">France</country><wicri:regionArea>Univ Paris 11, Villejuif</wicri:regionArea><wicri:noRegion>Villejuif</wicri:noRegion><wicri:noRegion>Villejuif</wicri:noRegion></affiliation></author><author><name sortKey="Rathouz, Paul J" sort="Rathouz, Paul J" uniqKey="Rathouz P" first="Paul J." last="Rathouz">Paul J. Rathouz</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Illinois</region></placeName><wicri:cityArea>Department of Health Studies, University of Chicago, Chicago</wicri:cityArea></affiliation></author><author><name sortKey="Moisan, Frederic" sort="Moisan, Frederic" uniqKey="Moisan F" first="Frédéric" last="Moisan">Frédéric Moisan</name><affiliation wicri:level="1"><country xml:lang="fr">France</country><wicri:regionArea>INSERM, U708, Paris</wicri:regionArea><placeName><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="1"><country xml:lang="fr">France</country><wicri:regionArea>UPMC, Univ Paris 06, Paris</wicri:regionArea><placeName><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Galanaud, Jean Hilippe" sort="Galanaud, Jean Hilippe" uniqKey="Galanaud J" first="Jean-Philippe" last="Galanaud">Jean-Philippe Galanaud</name><affiliation wicri:level="1"><country xml:lang="fr">France</country><wicri:regionArea>INSERM, U708, Paris</wicri:regionArea><placeName><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="1"><country xml:lang="fr">France</country><wicri:regionArea>UPMC, Univ Paris 06, Paris</wicri:regionArea><placeName><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Delemotte, Bernard" sort="Delemotte, Bernard" uniqKey="Delemotte B" first="Bernard" last="Delemotte">Bernard Delemotte</name><affiliation wicri:level="1"><country xml:lang="fr">France</country><wicri:regionArea>Mutualité Sociale Agricole, Bagnolet</wicri:regionArea><wicri:noRegion>Bagnolet</wicri:noRegion><wicri:noRegion>Bagnolet</wicri:noRegion></affiliation></author><author><name sortKey="Alperovitch, Annick" sort="Alperovitch, Annick" uniqKey="Alperovitch A" first="Annick" last="Alpérovitch">Annick Alpérovitch</name><affiliation wicri:level="1"><country xml:lang="fr">France</country><wicri:regionArea>INSERM, U708, Paris</wicri:regionArea><placeName><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="1"><country xml:lang="fr">France</country><wicri:regionArea>UPMC, Univ Paris 06, Paris</wicri:regionArea><placeName><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Tzourio, Christophe" sort="Tzourio, Christophe" uniqKey="Tzourio C" first="Christophe" last="Tzourio">Christophe Tzourio</name><affiliation wicri:level="1"><country xml:lang="fr">France</country><wicri:regionArea>INSERM, U708, Paris</wicri:regionArea><placeName><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="1"><country xml:lang="fr">France</country><wicri:regionArea>UPMC, Univ Paris 06, Paris</wicri:regionArea><placeName><settlement type="city">Paris</settlement></placeName></affiliation></author></analytic><monogr></monogr><series><title level="j">Annals of Neurology</title><title level="j" type="abbrev">Ann Neurol.</title><idno type="ISSN">0364-5134</idno><idno type="eISSN">1531-8249</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2009-10">2009-10</date><biblScope unit="volume">66</biblScope><biblScope unit="issue">4</biblScope><biblScope unit="page" from="494">494</biblScope><biblScope unit="page" to="504">504</biblScope></imprint><idno type="ISSN">0364-5134</idno></series><idno type="istex">80A003FEED147605130B49003FBB3D593BF89233</idno><idno type="DOI">10.1002/ana.21717</idno><idno type="ArticleID">ANA21717</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0364-5134</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Objective: We studied the relation between Parkinson disease (PD) and professional exposure to pesticides in a community‐based case‐control study conducted in a population characterized by a high prevalence of exposure. Our objective was to investigate the role of specific pesticide families and to perform dose‐effect analyses. Methods: PD cases (n = 224) from the Mutualité Sociale Agricole (France) were matched to 557 controls free of PD affiliated with the same health insurance. Pesticide exposure was assessed using a 2‐phase procedure, including a case‐by‐case expert evaluation. Analyses of the relation between PD and professional exposure to pesticides were first performed overall and by broad category (insecticides, fungicides, herbicides). Analyses of 29 pesticide families defined based on a chemical classification were restricted to men. Multiple imputation was used to impute missing values of pesticide families. Data were analyzed using conditional logistic regression, both using a complete‐case and an imputed dataset. Results: We found a positive association between PD and overall professional pesticide use (odds ratio [OR] = 1.8, 95% confidence interval [CI] = 1.1–3.1), with a dose‐effect relation for the number of years of use (p = 0.01). In men, insecticides were associated with PD (OR = 2.2, 95% CI = 1.1–4.3), in particular organochlorine insecticides (OR = 2.4, 95% CI = 1.2–5.0). These associations were stronger in men with older onset PD than in those with younger onset PD, and were characterized by a dose‐effect relation in the former group. Interpretation: Our results support an association between PD and professional pesticide exposure, and show that some pesticides (ie, organochlorine insecticides) may be more particularly involved. Ann Neurol 2009;66:494–504</div></front></TEI><affiliations><list><country><li>France</li><li>États-Unis</li></country><region><li>Illinois</li></region><settlement><li>Paris</li></settlement></list><tree><country name="France"><noRegion><name sortKey="Elbaz, Alexis" sort="Elbaz, Alexis" uniqKey="Elbaz A" first="Alexis" last="Elbaz">Alexis Elbaz</name></noRegion><name sortKey="Alperovitch, Annick" sort="Alperovitch, Annick" uniqKey="Alperovitch A" first="Annick" last="Alpérovitch">Annick Alpérovitch</name><name sortKey="Alperovitch, Annick" sort="Alperovitch, Annick" uniqKey="Alperovitch A" first="Annick" last="Alpérovitch">Annick Alpérovitch</name><name sortKey="Clavel, Jacqueline" sort="Clavel, Jacqueline" uniqKey="Clavel J" first="Jacqueline" last="Clavel">Jacqueline Clavel</name><name sortKey="Clavel, Jacqueline" sort="Clavel, Jacqueline" uniqKey="Clavel J" first="Jacqueline" last="Clavel">Jacqueline Clavel</name><name sortKey="Delemotte, Bernard" sort="Delemotte, Bernard" uniqKey="Delemotte B" first="Bernard" last="Delemotte">Bernard Delemotte</name><name sortKey="Elbaz, Alexis" sort="Elbaz, Alexis" uniqKey="Elbaz A" first="Alexis" last="Elbaz">Alexis Elbaz</name><name sortKey="Elbaz, Alexis" sort="Elbaz, Alexis" uniqKey="Elbaz A" first="Alexis" last="Elbaz">Alexis Elbaz</name><name sortKey="Galanaud, Jean Hilippe" sort="Galanaud, Jean Hilippe" uniqKey="Galanaud J" first="Jean-Philippe" last="Galanaud">Jean-Philippe Galanaud</name><name sortKey="Galanaud, Jean Hilippe" sort="Galanaud, Jean Hilippe" uniqKey="Galanaud J" first="Jean-Philippe" last="Galanaud">Jean-Philippe Galanaud</name><name sortKey="Moisan, Frederic" sort="Moisan, Frederic" uniqKey="Moisan F" first="Frédéric" last="Moisan">Frédéric Moisan</name><name sortKey="Moisan, Frederic" sort="Moisan, Frederic" uniqKey="Moisan F" first="Frédéric" last="Moisan">Frédéric Moisan</name><name sortKey="Tzourio, Christophe" sort="Tzourio, Christophe" uniqKey="Tzourio C" first="Christophe" last="Tzourio">Christophe Tzourio</name><name sortKey="Tzourio, Christophe" sort="Tzourio, Christophe" uniqKey="Tzourio C" first="Christophe" last="Tzourio">Christophe Tzourio</name></country><country name="États-Unis"><region name="Illinois"><name sortKey="Rathouz, Paul J" sort="Rathouz, Paul J" uniqKey="Rathouz P" first="Paul J." last="Rathouz">Paul J. Rathouz</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/ParkinsonV1/Data/France/Analysis
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000074 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/France/Analysis/biblio.hfd -nk 000074 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= ParkinsonV1
|flux= France
|étape= Analysis
|type= RBID
|clé= ISTEX:80A003FEED147605130B49003FBB3D593BF89233
|texte= Professional exposure to pesticides and Parkinson disease
}}
| This area was generated with Dilib version V0.6.23. |  |